Cerebral aspergillosis is a life-threatening complication in liver transplant recipients, with mortality rates approaching 100%; treatment with amphotericin B is of limited efficacy because of its poor distribution in the cerebrospinal fluid and its systemic side effects. We report the case of a liver transplant recipient who developed recurrent cerebral Aspergillus fumigatus infection, and was successfully treated by combined surgical excision of the lesion and administration of liposomal amphotericin B. This first report of long-term complication-free survival in a liver transplant recipient suggests that therapy with liposomal amphotericin B may reduce the risk of recurrence of cerebral aspergillosis in these immunocompromised patients

Iemmolo, R., Rossanese, A., Rotilio, A., Mattisi, G., Gerunda, G., Merenda, R., et al. (1998). Cerebral aspergillosis in a liver transplant recipient: a case report of long-term survival after combined treatment with liposomal amphotericin B and surgery. JOURNAL OF HEPATOLOGY, 28(3), 518-522 [10.1016/S0168-8278(98)80329-2].

Cerebral aspergillosis in a liver transplant recipient: a case report of long-term survival after combined treatment with liposomal amphotericin B and surgery

STRAZZABOSCO, MARIO
1998

Abstract

Cerebral aspergillosis is a life-threatening complication in liver transplant recipients, with mortality rates approaching 100%; treatment with amphotericin B is of limited efficacy because of its poor distribution in the cerebrospinal fluid and its systemic side effects. We report the case of a liver transplant recipient who developed recurrent cerebral Aspergillus fumigatus infection, and was successfully treated by combined surgical excision of the lesion and administration of liposomal amphotericin B. This first report of long-term complication-free survival in a liver transplant recipient suggests that therapy with liposomal amphotericin B may reduce the risk of recurrence of cerebral aspergillosis in these immunocompromised patients
Articolo in rivista - Articolo scientifico
cerebral aspergillosis; liposomal amphotericin B; liver transplantation
English
1998
28
3
518
522
none
Iemmolo, R., Rossanese, A., Rotilio, A., Mattisi, G., Gerunda, G., Merenda, R., et al. (1998). Cerebral aspergillosis in a liver transplant recipient: a case report of long-term survival after combined treatment with liposomal amphotericin B and surgery. JOURNAL OF HEPATOLOGY, 28(3), 518-522 [10.1016/S0168-8278(98)80329-2].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/1302
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