Breast cancer (BC) recovery has increased in recent years thanks to efforts of Omics-based research in this field. However, despite the important results obtained, BC remains a complex multifactorial pathology that is difficult to treat appropriately. Caveolin-1 (CAV1), the basic constituent protein of specialized plasma membrane invaginations called caveolae, is emerging as a potential therapeutic biomarker in BC. This factor may modulate BC response to chemotherapy and radiation therapy. In addition, recent reports describe the key role of CAV1 during cell response to oxidative stress. The aim of the present review was to describe the biological roles of CAV1 in BC considering its contrasting dual functions as an oncogene and as a tumor suppressor. In addition, we report on how CAV1 may contribute to tumor cell response to ionizing radiation treatment. Finally, new roles of CAV1 in BC both on epithelium and stroma may be useful as prognostic indicators for patient treatment and help clinicians in the selection of the best personalized therapy.

Pucci, M., Bravatà, V., Forte, G., Cammarata, F., Messa, M., Gilardi, M., et al. (2015). Caveolin-1, breast cancer and ionizing radiation. CANCER GENOMICS & PROTEOMICS, 12(3), 143-152.

Caveolin-1, breast cancer and ionizing radiation

MESSA, MARIA CRISTINA;GILARDI, MARIA CARLA
Penultimo
;
2015

Abstract

Breast cancer (BC) recovery has increased in recent years thanks to efforts of Omics-based research in this field. However, despite the important results obtained, BC remains a complex multifactorial pathology that is difficult to treat appropriately. Caveolin-1 (CAV1), the basic constituent protein of specialized plasma membrane invaginations called caveolae, is emerging as a potential therapeutic biomarker in BC. This factor may modulate BC response to chemotherapy and radiation therapy. In addition, recent reports describe the key role of CAV1 during cell response to oxidative stress. The aim of the present review was to describe the biological roles of CAV1 in BC considering its contrasting dual functions as an oncogene and as a tumor suppressor. In addition, we report on how CAV1 may contribute to tumor cell response to ionizing radiation treatment. Finally, new roles of CAV1 in BC both on epithelium and stroma may be useful as prognostic indicators for patient treatment and help clinicians in the selection of the best personalized therapy.
Articolo in rivista - Review Essay
Biomarker; Breast cancer; CAV1; Ionizing radiation; Review;
CAV1; biomarker; breast cancer; ionizing radiation; review; Animals; Biomarkers, Tumor; Breast Neoplasms; Caveolin 1; Cell Transformation, Neoplastic; Female; Gene Expression Regulation, Neoplastic; Humans; Molecular Targeted Therapy; Radiotherapy; Receptor, Epidermal Growth Factor; Radiation, Ionizing
English
2015
12
3
143
152
none
Pucci, M., Bravatà, V., Forte, G., Cammarata, F., Messa, M., Gilardi, M., et al. (2015). Caveolin-1, breast cancer and ionizing radiation. CANCER GENOMICS & PROTEOMICS, 12(3), 143-152.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/114853
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