To determine whether coinfection with HTLV-II influences the course of HIV-1 infection, we evaluated the progression from asymptomatic HIV infection (CDC group II) to persistent generalized lymphadenopathy (CDC group III) to AIDS-related complex (CDC group IVA) to full-blown AIDS (CDC group IVC) to death from AIDS in two groups of HIV-seropositive intravenous drug users (IVDUs). The first group consisted of 123 patients infected with HIV-1 only, and the second comprised 22 patients with serological and molecular evidence of HTLV-II/HIV-1 coinfection. Results of the immunological and clinical follow-up indicated a greater likelihood of developing persistent generalized lymphadenopathy among individuals infected with HIV-1 alone than among those coinfected with HTLV-II. However, no statistical difference was detected between the two groups in the depletion of CD4+ cells, the temporal decrease of the CD4/CD8 ratio, or the progression to ARC or AIDS or to death from AIDS. These findings suggest that HTLV-II may have no effect on the clinical evolution of HIV infection in IVDUs, which may be explained by the lack of pathogenicity of the HTLV-II coinfecting strain(s) and/or other still unclear biological or immunological cofactors or mechanisms.

Visconti, A., Visconti, L., Bellocco, R., Binkin, N., Colucci, G., Vernocchi, L., et al. (1993). HTLV-II/HIV-1 coinfection and risk for progression to AIDS among intravenous drug users. JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 6(11), 1228-1237.

HTLV-II/HIV-1 coinfection and risk for progression to AIDS among intravenous drug users

BELLOCCO, RINO;
1993

Abstract

To determine whether coinfection with HTLV-II influences the course of HIV-1 infection, we evaluated the progression from asymptomatic HIV infection (CDC group II) to persistent generalized lymphadenopathy (CDC group III) to AIDS-related complex (CDC group IVA) to full-blown AIDS (CDC group IVC) to death from AIDS in two groups of HIV-seropositive intravenous drug users (IVDUs). The first group consisted of 123 patients infected with HIV-1 only, and the second comprised 22 patients with serological and molecular evidence of HTLV-II/HIV-1 coinfection. Results of the immunological and clinical follow-up indicated a greater likelihood of developing persistent generalized lymphadenopathy among individuals infected with HIV-1 alone than among those coinfected with HTLV-II. However, no statistical difference was detected between the two groups in the depletion of CD4+ cells, the temporal decrease of the CD4/CD8 ratio, or the progression to ARC or AIDS or to death from AIDS. These findings suggest that HTLV-II may have no effect on the clinical evolution of HIV infection in IVDUs, which may be explained by the lack of pathogenicity of the HTLV-II coinfecting strain(s) and/or other still unclear biological or immunological cofactors or mechanisms.
Articolo in rivista - Articolo scientifico
Acquired Immunodeficiency Syndrome; Adult; CD4-CD8 Ratio; CD4-Positive T-Lymphocytes; Chi-Square Distribution; Cohort Studies; Female; Follow-Up Studies; HIV Antibodies; HIV Infections; HTLV-I Infections; HTLV-II Infections; Humans; Immunoglobulins; Leukocyte Count; Male; Risk Factors; Substance Abuse, Intravenous; Survival Analysis; Time Factors; HIV-1
English
1993
6
11
1228
1237
none
Visconti, A., Visconti, L., Bellocco, R., Binkin, N., Colucci, G., Vernocchi, L., et al. (1993). HTLV-II/HIV-1 coinfection and risk for progression to AIDS among intravenous drug users. JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 6(11), 1228-1237.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/103633
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