For more than a century, aspirin has been used for the acute treatment of primary headaches. However, the many formulations available are characterized by differences in the pharmacokinetic profile that could affect therapy effectiveness.The formulations of aspirin affect the speed of absorption of the drug. This feature, in turn, moduates the peak plasmatic concentration (the faster the absorption, the higher the peak plasmatic concentration of aspirin). Recently, a new formulation, consisting in a micronized tablet with an effervescent nucleus, has been shown to be comparable to the formulations associated to the faster absorption. The efficacy of aspirin in migraine is well characterized: the drug is able to rapidly reduce pain and restore functionality, acting also on associated symptoms, in a manner comparable to that of oral sumatriptan. In tension-type headache, aspirin acts in a dose-dependent fashion. The safety profile of the drug is favorable: gastrointestinal complaints are generally mild in intensity and with an incidence comparable to that of ibuprofen and paracetamol.According to international guidelines, aspirin should be considered as first-line therapy in primary headaches. Formulations that allow fast absorption, like the new micronized tablets, and portability, are to be preferred.

Lecchi, M., D'Alonzo, L., Negro, A., Martelletti, P. (2014). Pharmacokinetics and safety of a new aspirin formulation for the acute treatment of primary headaches. EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 10(10), 1381-1395 [10.1517/17425255.2014.952631].

Pharmacokinetics and safety of a new aspirin formulation for the acute treatment of primary headaches

LECCHI, MARZIA MARIA
Primo
;
2014

Abstract

For more than a century, aspirin has been used for the acute treatment of primary headaches. However, the many formulations available are characterized by differences in the pharmacokinetic profile that could affect therapy effectiveness.The formulations of aspirin affect the speed of absorption of the drug. This feature, in turn, moduates the peak plasmatic concentration (the faster the absorption, the higher the peak plasmatic concentration of aspirin). Recently, a new formulation, consisting in a micronized tablet with an effervescent nucleus, has been shown to be comparable to the formulations associated to the faster absorption. The efficacy of aspirin in migraine is well characterized: the drug is able to rapidly reduce pain and restore functionality, acting also on associated symptoms, in a manner comparable to that of oral sumatriptan. In tension-type headache, aspirin acts in a dose-dependent fashion. The safety profile of the drug is favorable: gastrointestinal complaints are generally mild in intensity and with an incidence comparable to that of ibuprofen and paracetamol.According to international guidelines, aspirin should be considered as first-line therapy in primary headaches. Formulations that allow fast absorption, like the new micronized tablets, and portability, are to be preferred.
Articolo in rivista - Articolo scientifico
aspirin; headache treatment; micronized aspirin; migraine; pharmacokinetics; safety; speed of action; tension-type headache; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dose-Response Relationship, Drug; Headache; Humans; Migraine Disorders; Practice Guidelines as Topic; Sumatriptan; Tablets
English
2014
10
10
1381
1395
none
Lecchi, M., D'Alonzo, L., Negro, A., Martelletti, P. (2014). Pharmacokinetics and safety of a new aspirin formulation for the acute treatment of primary headaches. EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 10(10), 1381-1395 [10.1517/17425255.2014.952631].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/101361
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