Despite the relevance of carbohydrates as cues in eliciting specific biological responses, glycans have been rarely exploited in the study of neuronal physiology. We report thereby the study of the effect of neoglucosylated collagen matrices on neuroblastoma F11 cell line behavior. Morphological and functional analysis clearly showed that neoglucosylated collagen matrices were able to drive cells to differentiate. These data show for the first time that F11 cells can be driven from proliferation to differentiation without the use of chemical differentiating agents. Our work may offer to cell biologists new opportunities to study neuronal cell differentiation mechanisms in a cell environment closer to physiological conditions.

Russo, L., Sgambato, A., Lecchi, M., Pastori, V., Raspanti, M., Natalello, A., et al. (2014). Neoglucosylated Collagen Matrices Drive Neuronal Cells to Differentiate. ACS CHEMICAL NEUROSCIENCE, 5, 261-265 [10.1021/cn400222s].

Neoglucosylated Collagen Matrices Drive Neuronal Cells to Differentiate

RUSSO, LAURA;SGAMBATO, ANTONELLA;LECCHI, MARZIA MARIA;PASTORI, VALENTINA;NATALELLO, ANTONINO;DOGLIA, SILVIA MARIA;NICOTRA, FRANCESCO;CIPOLLA, LAURA FRANCESCA
2014

Abstract

Despite the relevance of carbohydrates as cues in eliciting specific biological responses, glycans have been rarely exploited in the study of neuronal physiology. We report thereby the study of the effect of neoglucosylated collagen matrices on neuroblastoma F11 cell line behavior. Morphological and functional analysis clearly showed that neoglucosylated collagen matrices were able to drive cells to differentiate. These data show for the first time that F11 cells can be driven from proliferation to differentiation without the use of chemical differentiating agents. Our work may offer to cell biologists new opportunities to study neuronal cell differentiation mechanisms in a cell environment closer to physiological conditions.
Articolo in rivista - Articolo scientifico
Neuroblastoma F11 cell line, carbohydrates, collagen film, biomaterial
English
13-mar-2014
5
261
265
none
Russo, L., Sgambato, A., Lecchi, M., Pastori, V., Raspanti, M., Natalello, A., et al. (2014). Neoglucosylated Collagen Matrices Drive Neuronal Cells to Differentiate. ACS CHEMICAL NEUROSCIENCE, 5, 261-265 [10.1021/cn400222s].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/51288
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