A set of new metabolically stable arabinose 5-phosphate analogues possessing phosphate mimetic groups at position 5 was synthesised. Their ability to interact with arabinose 5-phosphate isomerase from Pseudomonas aeruginosa was evaluated by STD-NMR studies. The synthesised compounds were also characterised for their activity in vivo on P. aeruginosa and E. coli strains. Unfortunately, none of the synthesised compounds was able neither to bind API nor to inhibit bacterial growth.
Cipolla, L., Airoldi, C., Sperandeo, P., Gianera, S., Polissi, A., Nicotra, F., et al. (2014). Synthesis and biological evaluation of arabinose 5-phosphate mimics modified at position five. CARBOHYDRATE RESEARCH, 389, 186-191 [10.1016/j.carres.2014.01.004].
Synthesis and biological evaluation of arabinose 5-phosphate mimics modified at position five
CIPOLLA, LAURA FRANCESCA;AIROLDI, CRISTINA;SPERANDEO, PAOLA;GIANERA, SERENA;POLISSI, ALESSANDRA;NICOTRA, FRANCESCO;GABRIELLI, LUCA
2014
Abstract
A set of new metabolically stable arabinose 5-phosphate analogues possessing phosphate mimetic groups at position 5 was synthesised. Their ability to interact with arabinose 5-phosphate isomerase from Pseudomonas aeruginosa was evaluated by STD-NMR studies. The synthesised compounds were also characterised for their activity in vivo on P. aeruginosa and E. coli strains. Unfortunately, none of the synthesised compounds was able neither to bind API nor to inhibit bacterial growth.
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