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Authors: Bartolomucci, A; Bresciani, E; Bulgarelli, I; Rigamonti, A; Pascucci, T; Levi, A; Possenti, R; Torsello, AB; Locatelli, V; Muller, E; Moles, A
Title: Chronic intracerebroventricular injection of TLQP-21 prevents high fat diet induced weight gain in fast weight-gaining mice
English abstract: The vgf gene regulates energy homeostasis and the VGF-derived peptide TLQP-21 centrally exerts catabolic effects in mice and hamsters. Here, we investigate the effect of chronic intracerebroventricular (icv) injection of TLQP-21 in mice fed high fat diet (HFD). Fast weight-gaining mice injected with the peptide or cerebrospinal fluid were selected for physiological, endocrine, and molecular analysis. TLQP-21 selectively inhibited the increase in body weight and epididymal white adipose tissue (eWAT) weight induced by HFD in control animals despite both groups having a similar degree of hyperphagia. TLQP-21 normalized the increase in leptin and decrease in ghrelin while increasing epinephrine and epinephrine/norepinephrine ratio when compared to values in controls. Finally, HFD-TLQP-21 mice showed a selective increase of eWAT beta3-adrenergic receptor mRNA. Peroxisome-proliferator-activated-receptor-delta and hormone-sensing-lipase mRNA were also upregulated. In conclusion, chronic icv infusion of TLQP-21 prevented the early phase of diet-induced obesity despite overfeeding. These effects were paralleled by activation of catabolic pathways within the eWAT. Our results further support a role for TLQP-21 as a catabolic neuropeptide.
Keywords: TLQP-21, feeding, diet, mouse
MIUR Subject : Settore BIO/14 - Farmacologia
ISO Language : eng
Issue Date: 2009
Circulation: Rilevanza internazionale
Type: Articolo in rivista
Referee: Esperti anonimi
Impact Factor: Con Impact Factor ISI
Publication Status: Pubblicato
Citation: Bartolomucci, A., Bresciani, E., Bulgarelli, I., Rigamonti, A., Pascucci, T., Levi, A., et al. (2009). Chronic intracerebroventricular injection of TLQP-21 prevents high fat diet induced weight gain in fast weight-gaining mice. Genes and nutrition, 4, 49-57.
Appears in Collections:Pubblicazioni >01 - Articolo su rivista

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